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Case of the Week 259 
What's the most likely diagnosis?
- 71 year-old male with hip pain
- Osteoarthritis
- Ankylosing spondylitis
- Paget's disease
- Metastatic prostate carcinoma
- Multiple myeloma
Answer:
3. Paget's disease
More (Click Discussion Tab)
Paget's Disease
General Considerations
- Multifocal chronic skeletal disease due to chronic paramyxoviral infection
- Prevalence
- 3% of individuals >40 years
- 10% of persons >80 years
- Unusual <40 years
- M:F = 2:1
- Histology
- Increased resorption and increased bone formation
- Newly formed bone is abnormally soft with disorganized trabecular pattern
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